m1Ψ mRNA suppresses cellular immunity
Treatment with m1Ψ mRNA is associated with a reduction of effector T cells and the development of regulatory T cells
UPDATE: New paper from Drs Seneff and Mccollough - https://www.researchgate.net/publication/357994624_Innate_Immune_Suppression_by_SARS-CoV-2_mRNA_Vaccinations_The_role_of_G-quadruplexes_exosomes_and_microRNAs
m1Ψ mRNA promotes regulatory T cell growth (by design), which suppresses cellular immunity.
The last author of this paper appears to be the CEO of Bio-N-Tech: “A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis”
https://pubmed.ncbi.nlm.nih.gov/33414215/
Credit to JPSikaDoctor for analyzing this paper. 1
From the paper’s abstract:
[Treatment with m1Ψ mRNA] is associated with a reduction of effector T cells and the development of regulatory T cell (Tregcell) populations. Notably, these Treg cells execute strong bystander immunosuppression and thus improve disease induced by cognate and noncognate autoantigens.
The paper appears to show that m1Ψ mRNA2 therapy leads to fewer DCs, CD4, CD8, B, and NK cells; and Interferon-alpha, compared to prototypical Uridine (U) mRNA therapy. In fact, the cellular immune response to m1Ψ mRNA was similar to the immune response to saline used as control. Which is because m1Ψ promotes Treg cells.
In other words, m1Ψ mRNA was used to simulate natural immune tolerance through suppression of cell-mediated immunity.
Thus, if an m1Ψ mRNA therapeutic were to be applied prophylactically for an infectious disease, the theoretical benefit is that the body would be less likely to cause a cytokine storm when presented with the wild type antigen. 3 However, JPSikaDoctor says due to cellular immune suppression, infection4 would be more likely to occur. The main purpose of such a product would be to lessen severe symptoms, although it would not provide sterilizing immunity.
Furthermore, JPSikaDoctor also notes that if antibodies wane over time, and cellular immunity remains suppressed, then continuous boosters might be needed to maintain antibody immunity. And even that would only work if the disease did not mutate and the ancestral antibodies could still bind to the same antigen.
Which leads to some questions. How long does the cellular immune suppression last? Could we see latent viruses reactivate? Could we see rapid cancer growth? What would happen if Treg cells waned over time, but the antigen remained anchored to the body (or attached to an immune cell, such as a monocyte)?5
His videos are in Japanese. The full version is posted to Nico Video. https://nico.ms/sm397809
m1Ψ mRNA apparently is created from (U) mRNA by replacing Uridine with 1-methylpseudouridine.
The paper argues that the cellular immune suppression mechanism does not impair the capability to mount an immune response against other antigens. Not sure how that works. JPSikaDoctor thinks Figures 2.B, 2.C and 2.D show a degraded cellular immune response. He does note Figure 2.G shows that antibody immune response is boosted.
Spreading of the pathogen within the body.