NIH confirms: SARS-2 mRNA and S protein translocate to cell nucleus

Whoops.

A recent NIAID / NIH study found the following:

The spike (S) protein appears to be a major pathogenic factor that contributes to the unique pathogenesis of SARS-CoV-2.

Although the S protein is a surface transmembrane type 1 glycoprotein, it has been predicted to be translocated into the nucleus due to the novel nuclear localization signal (NLS) “PRRARSV”, which is absent from the S protein of other coronaviruses.

Indeed, S proteins translocate into the nucleus in SARS-CoV-2-infected cells. To our surprise, S mRNAs also translocate into the nucleus.

S mRNA colocalizes with S protein, aiding the nuclear translocation of S mRNA.

While nuclear translocation of nucleoprotein (N) has been shown in many coronaviruses, the nuclear translocation of both S mRNA and S protein reveals a novel pathogenic feature of SARS-CoV-2.

This seems to contradict CDC guidance:

Who’s spreading misinformation?